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Structural basis to design multi-epitope vaccines against Novel Coronavirus 19 (COVID19) infection, the ongoing pandemic emergency: an in silico approach

biorxiv. 2020-03; 
Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Rupinder Kaur, Ruchi Kiran Badyal, Ajay Kumar Saxena, Ho-Joon Shin, Michael Kolbe, Kailash C Pandey
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Molecular Biology Tools The generated cDNA of both the MEVs were further analysed by GenScript Rare Codon Analysis Tool (https://wwwgenscriptcom/tools/rare-codon-analysis) The tool analyses the GC content, Codon Adaptation Index (CAI) and the Tandem rare codon frequency for a given cDNA (Morla et al, 2016; Wu et al, 2010)  Get A Quote

摘要

The 2019 novel coronavirus (COVID19 / Wuhan coronavirus), officially named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a positive-sense single-stranded RNA coronavirus. SARS-CoV-2 causes the contagious COVID19 disease also known as 2019-nCoV acute respiratory disease and has led to the ongoing 2019–20 pandemic COVID19 outbreak. The effective countermeasures against SARS-CoV-2 infection requires the design and development of specific and effective vaccine candidate. In the present study we have screened 38 CTL, 42 HTL and 12 B cell epitopes by utilizing different in silico tools. The screened epitopes were further validated for their binding with their respective HLA allele binders and ... More

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