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Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly

Nat Struct Mol Biol. 2018; 
Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, 0, , Vos HR, Tora L, 0, , Heck AJR, Timmers HTM, , Berger I
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ORF cDNA Clones/MolecularCloud TAF9- and TAF5- mutant cDNAs were purchased from GenScript. Get A Quote

摘要

TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit compositions exist and several TFIID subunits are shared with other complexes, thereby conveying precise cellular control of subunit allocation and functional assembly of this essential transcription factor. However, the molecular mechanisms that underlie the regulation of TFIID remain poorly understood. Here we use quantitative proteomics to examine TFIID submodules and assembly mechanisms in human cells. Structural and mutational analysis of the cytoplasmic TAF5-TAF6-TAF9 submodule identified novel interactions that are crucial for TFIID integrity and for allocation of TAF9 to TFIID or the Spt-Ada-Gcn5 acetyltra... More

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