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Expansion of SARS-CoV-2-specific Antibody-secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients

biorxiv. 2020-04;

View ORCID ProfileRenata Varnaitė, View ORCID ProfileMarina García, Hedvig Glans, View ORCID ProfileKimia T. Maleki, View ORCID ProfileJohn Tyler Sandberg, View ORCID ProfileJanne Tynell, View ORCID ProfileWanda Christ, Nina Lagerqvist, View ORCID ProfileHilmir Asgeirsson, View ORCID ProfileHans-Gustaf Ljunggren, Gustaf Ahlén, View ORCID ProfileLars Frelin, Matti Sällberg, Kim Blom, Jonas Klingström, View ORCID ProfileSara Gredmark-Russ

Products/Services Used	Details	Operation
DNA Sequencing	gene, RNAse P were procured as clones from GenScript, USA. The sequences 136 of RNA clones of the genes of interest are as follows:	Get A Quote

摘要

COVID-19, caused by SARS-CoV-2, emerged in late 2019 and has since become a global pandemic. Pathogen-specific antibodies are typically a major predictor of protective immunity, yet B cell and antibody responses during COVID-19 are not fully understood. Here, we analyzed antibody-secreting cell (ASC) and antibody responses in twenty hospitalized COVID-19 patients. We observed a significant expansion of SARS-CoV-2 nucleocapsid protein-specific ASCs in all twenty COVID-19 patients using a multicolor FluoroSpot assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing antibodies by the time of sampling. Additionally, we found that SARS-CoV-2-specific IgA, IgG and IgM antibody levels positively correl... More