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Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic …

Growth Hormone & IGF Research. 2016-12;

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Biochemicals	… COVID-19 campus closures … While the role of IGFBPs in other tissues such as bone is relatively well understood [18], [19], [20], [21], there is a … encoding the murine IGFBP-2 coding region flanked by SacII and HindIII recognition sites was purchased from GenScript (New Jersey …	Get A Quote

摘要

The insulin-like growth factor binding proteins (IGFBPs) are thought to modulate cell size and homeostasis via IGF-I-dependent and -independent pathways. There is a considerable dearth of information regarding the function of IGFBPs in skeletal muscle, particularly their role in the pathophysiology of Duchenne muscular dystrophy (DMD). In this study we tested the hypothesis that intramuscular IGFBP-2 overexpression would ameliorate the pathology in mdx dystrophic mice.