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Early Release-Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA …

CDC. 2020-05; 
Karima Benameur1Comments to Author , Ankita Agarwal1, Sara C. Auld, Matthew P. Butters, Andrew S. Webster, Tugba Ozturk, J. Christina Howell, Leda C. Bassit, Alvaro Velasquez, Raymond F. Schinazi, Mark E. Mullins, and William T. Hu
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Molecular Biology Tools … We assessed CSF IgM by using an in-house ELISA against SARS-CoV-2 S1 or envelope (E) protein … We measured levels of plasma IgG against the receptor-binding domain of S1 by using a commercial ELISA (GenScript, https://www.genscript.com) at a 1:16 dilution … Get A Quote

摘要

Few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection have been conducted. We describe 3 patients with laboratory-confirmed coronavirus disease who showed development of encephalopathy and encephalitis. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM. One patient who died also had increased levels of anti?envelope protein IgM. CSF analysis also showed markedly increased levels of interleukin (IL) 6, IL-8, and IL-10, but severe acute respiratory syndrome coronavirus 2 was not identified in any CSF sampl... More

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