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Molecular Biology Tools | … We assessed CSF IgM by using an in-house ELISA against SARS-CoV-2 S1 or envelope (E) protein … We measured levels of plasma IgG against the receptor-binding domain of S1 by using a commercial ELISA (GenScript, https://www.genscript.com) at a 1:16 dilution … | Get A Quote |
Few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection have been conducted. We describe 3 patients with laboratory-confirmed coronavirus disease who showed development of encephalopathy and encephalitis. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM. One patient who died also had increased levels of anti?envelope protein IgM. CSF analysis also showed markedly increased levels of interleukin (IL) 6, IL-8, and IL-10, but severe acute respiratory syndrome coronavirus 2 was not identified in any CSF sampl... More