A highly convergent and concise synthesis of a triazole analogue of resorcylic acid lactone natural product LL‐Z1640‐2 has been achieved from easily accessible starting materials in six linear steps in 18 % overall yield. Biological evaluation confirmed the enone system of the natural product is crucial for its activity. The triazole analogue showed good activity (IC50 7.2 μM ) against MNK2 kinase, which is an emerging target for cancer chemotherapy.
A highly convergent and concise synthesis of a triazole analogue of resorcylic acid lactone natural product LL‐Z1640‐2 has been achieved from easily accessible starting materials in six linear steps in 18 % overall yield. Biological evaluation confirmed the enone system of the natural product is crucial for its activity. The triazole analogue showed good activity (IC50 7.2 μM ) against MNK2 kinase, which is an emerging target for cancer chemotherapy.