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The kinase activity of IRAK4 is required for IL-1R/TLR-induced TAK1-dependent NFkappa B activation.

J Biol Chem.. 2008-11; 
Jerzy Fraczek, Tae Whan Kim, Hui Xiao, Jianhong Yao, Qian Wen, Yali Li, Jean-Laurent Casanova, Juliusz Pryjma, and Xiaoxia Li. Department of Immunology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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Molecular Biology Tools ...The results were normalized with the housekeeping gene mouse-Actin. Primer sequences were designed using online tools from GenScript Corporation. For human IL-6 they were: forward 5'-AATGAGGAGACTTGCCTGGT-3', reverse 5'-GCAGGAACTGGATCAGGACT-3'. Human IL-8... Get A Quote

摘要

Two parallel interleukin-1 (IL-1)-mediated signaling pathways have been uncovered for IL-1R-TLR-mediated NFkappaB activation: TAK1-dependent and MEKK3-dependent pathways, respectively. The TAK1-dependent pathway leads to IKKalpha/beta phosphorylation and IKKbeta activation, resulting in classic NFkappaB activation through IkappaBalpha phosphorylation and degradation. The TAK1-independent MEKK3-dependent pathway involves IKKgamma phosphorylation and IKKalpha activation, resulting in NFkappaB activation through dissociation of phosphorylated IkappaBalpha from NFkappaB without IkappaBalpha degradation. IL-1 receptor-associated kinase 4 (IRAK4) belongs to the IRAK family of proteins and plays a critical role in IL-... More

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