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Two ferritin genes (MdFerH and MdFerL) are involved in iron homeostasis, antioxidation and immune defense in housefly Musca domestica

J Insect Physiol. 2020-06-01; 
Xinru Cao, Yongbao Li, Shuangshuang Li, Ting Tang, Fengsong Liu
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Recombinant Antibody Expression … respectively. After being induced by 1 mM isopropyl-β-D-thiogalactoside (IPTG) at 37℃ for 4 h, the cells were harvested by centrifugation and the recombinant proteins were purified using Ni-NTA Resin (GenScript, China). The … Get A Quote

摘要

Ferritin is a ubiquitous multi-subunit iron storage protein, made up of heavy chain and light chain subunits. In recent years, invertebrate ferritins have emerged as an important, yet largely underappreciated, component of host defense and antioxidant system. Here, two alternatively spliced transcripts encoding for a unique ferritin heavy chain homolog (MdFerH), and a transcript encoding for a light chain homolog (MdFerL) are cloned and characterized from Musca domestica. Comparing with MdFerH1, a fragment is absent at the 5' untranslated region of MdFerH2, where a putative iron response element is present. Amino acid sequence analysis shows that MdFerH possesses a strictly conserved ferroxidase site, while MdF... More

关键词

Ferritin, Innate immunity, Iron homeostasis, Musca domestica, Redox balance