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Custom RNAi Services> | … GACACGACUACUAUUCGCUTT. For a vector-based RNAi approach, a double-stranded short hairpin RNA (shRNA) was cloned into the BamHI-Hind III sites of the pRNAT-U6.1/neo-cGFP vector (GenScript Corporation). The … | Get A Quote |
It has been reported that nuclear factor of activated T cells (NFATC1) was up-regulated in cancers mediating malignant behaviors. However, the role of NFATC1 in ovarian cancer has not been elucidated. In the present study, we undertook to explore the clinicopathological significance of NFATC1 expression and the mechanism by which NFATC1 works in ovarian cancer. Expression status of NFATC1 was examined using immunohistochemistry. Both knockdown and re-expression of NFATC1 on ovarian cancer cells were employed to observe the effect overgrowth. It was found that NFATC1 was significantly overexpressed in ovarian cancer tissues in comparison with paired normal control tissues and that overexpression of NFATC1 was si... More