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Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting

FASEB J. 2020-07-01; 
Anna Kock, Filip Bergqvist, Julia Steinmetz, Lotta H M Elfman, Marina Korotkova, John Inge Johnsen, Per-Johan Jakobsson, Per Kogner, Karin Larsson
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Custom DNA/RNA Oligos … Design Guidelines,” Ambion Inc. at Ambion's web site; and by other web-based design tools at, for example, the Invitrogen, Dharmacon, Integrated DNA Technologies, Genscript, or Proligo web sites. Initial search parameters … Get A Quote

摘要

The majority of anti-cancer therapies target the proliferating tumor cells, while the tumor stroma, principally unaffected, survives, and provide a niche for surviving tumor cells. Combining tumor cell and stroma-targeting therapies thus have a potential to improve patient outcome. The neuroblastoma stroma contains cancer-associated fibroblasts expressing microsomal prostaglandin E synthase-1 (mPGES-1). mPGES-1-derived prostaglandin E (PGE ) is known to promote tumor growth through increased proliferation and survival of tumor cells, immune suppression, angiogenesis, and therapy resistance, and we, therefore, hypothesize that mPGES-1 constitutes an interesting stromal target. Here, we aimed to develop a relevan... More

关键词

PGE2, cancer, mPGES-1, microsomal prostaglandin E synthase-1, multicellular tumor spheroids