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Life expectancy and risk factors for early death in patients with severe thalassemia syndromes in South India

Blood Adv. 2020-04-01; 
Rakesh Dhanya, Amit Sedai, Kumari Ankita, Lalith Parmar, Rajat Kumar Agarwal, Santhosh Hegde, Gayathri Ramaswami, Ashwini Gowda, S Girija, Pooja Gujjal, H Pushpa, J Dasaratha Ramaiah, Chandrakala Karri, Sujata Jali, Neelavva Rayappa Tallur, U V Shenoy, Diana Pinto, Stalin Ramprakash, C P Raghuram, Deepa Trivedi, Xueyuan Cao, Lawrence Faulkner
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Monoclonal Antibody Services … Switzerland). Plasmids and retroviral transduction. The heavy and light chain sequences of the anti-IL6 human monoclonal antibody AME-19a were joined with a 15-amino acid [(G4S) 3 ] linker (GenScript; Nanjing, China). The … Get A Quote

摘要

In spite of advances in chelation therapy and screening of blood, mortality associated with the most common life-threatening noncommunicable disease of children in India, transfusion-dependent thalassemia (TDT), remains poorly defined. This study aims at estimating death rates and mortality risk factors associated with TDT. The clinical records of 1087 patients from 5 thalassemia centers in India were retrospectively analyzed from 2011 to 2018. Median patient age was 8.5 years, with 107 patients older than 18 years; 656 patients were male and 431 were female. Demographic details and clinical parameters were analyzed at presentation and at last visit. With 41 recorded deaths, actuarial survival at 26.9 years was... More

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