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Development of whole-cell and cell-free biosensors for the detection and differentiation of organic and inorganic forms of copper

Metallomics. 2020; 
Alan Costello, Joanne Parker, Martin Clynes, Richard Murphy
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GenParts™ DNA Fragments … Alan Costello ORCID logo * a , Joanne Parker b , Martin Clynes * a and Richard Murphy * b a National Institute for Cellular Biotechnology and SSPC-SFI Centre for Pharmaceuticals, Dublin City University, Dublin 9 … Insert DNA was ordered as DNA fragments from (GenScript) … Get A Quote

摘要

The modern world has seen exposure of bacterial communities to toxic metals at selective levels. This manifests itself both intentionally, through medicines and un-intentionally through waste streams. There is growing concern that selective exposure to metals may be linked to microbial resistance to antibiotics. For a microbe to become resistant to a specific metal it must first come in contact with it. The transition metal copper has the ability to enter bacterial cells without need for a copper specific uptake mechanism. Copper is commonly used as an antimicrobial in the healthcare industry, consumer products and as a growth promoter of livestock in the agricultural sector. Here we report a study into the upt... More

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