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Fc-Elabela fusion protein attenuates lipopolysaccharide-induced kidney injury in mice

Biosci Rep. 2020; 
Feng Xu, Huifen Zhou, Man Wu, Hong Zhang, Yixian Zhang, Qingbin Zhao, Robert Brown, Da-Wei Gong, Lining Miao
Products/Services Used Details Operation
GenParts™ DNA Fragments … Eugene, OR). ELA-21 peptide was made by GenScript (Piscataway, NJ) and Fc-ELA was made by conjugating the human IgG Fc fragment with ELA-21 at the N-terminus as previously described [21]. Animal studies. The animal … Get A Quote

摘要

Endotoxemia-induced acute kidney injury (AKI) is a common clinical condition that lacks effective treatments. Elabela (ELA) is a recently discovered kidney peptide hormone, encoded by the gene apela, and has been reported to improve cardio-renal outcomes in sepsis. However, ELA is a small peptide and is largely unsuitable for clinical use because of its short in vivo half-life. In the present study, we evaluated the potential renoprotective effects of a long-acting constant fragment (Fc)-ELA fusion protein in liposaccharide (LPS)-induced AKI in mice. LPS administration in mice for 5 days greatly lowered the gene expression of apela and impaired kidney function, as evidenced by elevated serum creatinine and the ... More

关键词

Elabela (ELA), acute kidney injury (AKI), fusion protein, liposaccharide (LPS)