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Meta-analysis of Diagnostic Performance of Serology Tests for COVID-19: Impact of Assay Design and Post-symptom-onset Intervals

Emerg Microbes Infect. 2020; 
Hongyu Wang, Jingwen Ai, Michael J Loeffelholz, Yi-Wei Tang, Wenhong Zhang
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Recombinant Antibody Expression … PBS containing soluble recombinant S1 protein (6 ug/ mL, Genscript, Piscataway, NJ), or PBS 94 containing soluble nucleocapsid protein (6 ug/mL, GenScript); thus, the final concentration of S1 95 protein or nucleocapsid protein in analyzed samples was 3 ug/mL … Get A Quote

摘要

Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests(NAATs), which is considered as the gold standard for diagnosing acute infection. However, when and how serology detection performs the best remains unknown. This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. Two authors independently searched PubMed, Cochrane library, Ovid, EBSCO for case-control, longitudinal and cohort studies that determined the diagnostic accuracy of serology tests in comparison with NAATs for SARS-CoV-2 RNA in COVID-19 cases and used QUADAS-2 for quality ... More

关键词

COVID-19, SARS-CoV-2, immunoassays, metanalysis, serology