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Differential combination immunotherapy requirements for inflamed (warm) tumors versus T cell excluded (cool) tumors: engage, expand, enable, and evolve

J Immunother Cancer. 2021-02; 
Kellsye P Fabian, Michelle R Padget, Rika Fujii, Jeffrey Schlom, James W Hodge
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Peptoid Synthesis HIV-gag peptides were synthesized by CPC Scientific and the JAK1, Ptgfr, and AH1 peptides were generated by GenScript? Get A Quote

摘要

background: Different types of tumors have varying susceptibility to immunotherapy and hence require different treatment strategies; these cover a spectrum ranging from 'hot' tumors or those with high mutational burden and immune infiltrates that are more amenable to targeting to 'cold' tumors that are more difficult to treat due to the fewer targetable mutations and checkpoint markers. We hypothesized that an effective anti-tumor response requires multiple agents that would (1) the immune response and generate tumor-specific effector cells; (2) the number and breadth of the immune effector cells; (3) the anti-tumor activity of these immune cells in the tumor microenvironment; and (4) the tumor response to ... More

关键词

cytokines, immunomodulation, immunotherapy, translational medical research, vaccination