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Species-specific quantification of circulating ebolavirus burden using VP40-derived peptide variants

PLoS Pathog. 2021-11; 
Qingbo Shu, Tara Kenny, Jia Fan, Christopher J Lyon, Lisa H Cazares, Tony Y Hu
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Monoclonal Antibody Services … A custom mouse monoclonal antibody specific for the EBOV VP40 peptide LGPGIPDHPLR and rabbit polyclonal antibodies specific for the BDBV VP40 peptide LRPILLPGK were generated for this study by GenScript (Nanjing, China), using synthetic peptides conjugated to the … Get A Quote

摘要

Six ebolavirus species are reported to date, including human pathogens Bundibugyo virus (BDBV), Ebola virus (EBOV), Sudan virus (SUDV), and Taï Forest virus (TAFV); non-human pathogen Reston virus (RESTV); and the plausible Bombali virus (BOMV). Since there are differences in the disease severity caused by different species, species identification and viral burden quantification are critical for treating infected patients timely and effectively. Here we developed an immunoprecipitation-coupled mass spectrometry (IP-MS) assay for VP40 antigen detection and quantification. We carefully selected two regions of VP40, designated as peptide 8 and peptide12 from the protein sequence that showed minor variations among... More

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