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SP-1154, a novel synthetic TGF-β inhibitor, alleviates obesity and hepatic steatosis in high-fat diet-induced mice

Biomed Pharmacother. 2021-11; 
Kisoo Pahk, Sang Gil Lee, Chanmin Joung, Eun-Ok Kim, Hyun Woo Kwon, Dong Hwi Kim, Jong-Ik Hwang, Sungeun Kim, Won-Ki Kim
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Custom DNA/RNA Oligos … Target gene mRNA template-specific primer sets were designed from GenScript (Piscataway, NJ, USA) and the levels of mRNA were normalized with the mRNA level of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) [26]. The gene expression levels were measured … Get A Quote

摘要

objective: Obesity-induced inflamed visceral adipose tissue (VAT) secretes pro-inflammatory cytokines thereby promoting systemic inflammation and insulin resistance which further exacerbate obesity-associated nonalcoholic fatty liver disease (NAFLD). Transforming growth factor (TGF)-β /Smad3 signaling plays a crucial role in the inflammatory events within the VAT. Here, we investigate whether SP-1154, a novel synthetic verbenone derivative, can inhibit TGF-β/Smad3 signaling thereby exhibiting a therapeutic effect against obesity-induced inflamed VAT and subsequent NAFLD in high-fat diet-induced mice. methods: NAFLD was induced by a high-fat diet (60% fat) for 20 weeks using the male C57BL/6 mice. SP-1154 (50... More

关键词

Inflammation, NAFLD, Obesity, Smad3, TGF-β, Visceral fat