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Chimeric VLPs Bearing VP60 from Two Serotypes of Are Protective against Both Viruses

Vaccines (Basel). 2021-09; 
Kevin P Dalton, Carmen Alvarado, Edel Reytor, Maria Del Carmen Nuñez, Ana Podadera, Diego Martínez-Alonso, Jose Manuel Martin Alonso, Ines Nicieza, Silvia Gómez-Sebastián, Romy M Dalton, Francisco Parra, José M Escribano
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DNA Sequencing … GmbH, Aidenbach, Germany) supplemented with 10% heat-inactivated foetal bovine serum (PAN-Biotech GmbH, Germany), gentamicin at … Gene sequence synthesis was carried out using the GenScript (Leiden, The Netherlands) service. The protein sequences encoded by the … Get A Quote

摘要

The VP60 capsid protein from rabbit haemorrhagic disease virus (RHDV), the causative agent of one of the most economically important disease in rabbits worldwide, forms virus-like particles (VLPs) when expressed using heterologous protein expression systems such as recombinant baculovirus, yeasts, plants or mammalian cell cultures. To prevent RHDV dissemination, it would be beneficial to develop a bivalent vaccine including both RHDV GI.1- and RHDV GI.2-derived VLPs to achieve robust immunisation against both serotypes. In the present work, we developed a strategy of production of a dual-serving RHDV vaccine co-expressing the VP60 proteins from the two RHDV predominant serotypes using CrisBio technology, which ... More

关键词

RHDV, Trichoplusia ni, baculovirus, bivalent vaccine, calicivirus, chimeric VLP