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Association of a GATA Binding Protein 4 Polymorphism with the Risk of Hypospadias in the Chinese Children

Urol Int. 2021-09; 
Jiawei Chen, Xinhai Cui, Aiwu Li, Guowei Li, Fengyin Sun
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Custom Vector Construction … Reporter plasmids containing either the A or T allele of rs12458 were synthesized using the pGL3 promoter vector (GenScript China Inc., Nanjing, China). HEK-293 cell lines were used to investigate the influence of the rs12458 variant on reporter activity. The cells were seeded … Get A Quote

摘要

objective: GATA binding protein 4 (GATA4) has been implicated in the etiology of congenital malformation of the urogenital system. The present study investigated the influence of GATA4 polymorphisms on susceptibility to hypospadias. methods: We genotyped 4 potentially functional polymorphisms (rs12458, rs12825, rs884662, and rs904018) in GATA4 in the hospital-based case-control study including 410 child patients and 520 nonmalformed individuals by the TaqMan MGB method. Risk associations were assessed using unconditional logistic regression, adjusted for potential confounding factors. results: A significant association was found between rs12458 (3'-UTR of GATA4) and susceptibility to hypospadias (p = 0.008). Co... More

关键词

GATA binding protein 4, Genetic polymorphism, Hypospadias, Susceptibility