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Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants

Inflammopharmacology. 2021-08; 
Xiao-Qiang Yuan, Xu-Ming Zhang
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摘要

Inflammatory bowel diseases (IBDs) are chronic and recurrent diseases that often occur in young people and place a heavy burden on public health in both developed and developing countries. Melatonin has been confirmed to be useful in various diseases, including Alzheimer's disease, liver injuries and diseases, and cancers, while its role in IBDs remains unclear. To uncover the function of melatonin in IBDs, three intestinal models, including Caco-2 cells, 3D intestinal organoids and intestinal explants, were used. It was found that different concentrations of melatonin could significantly inhibit the expression levels of NFκB and its downstream cytokines, including IL6 and IL8 in Caco-2 cells (*P < 0.05, *... More

关键词

Inflammation, Intestinal cells, Intestinal explants, Melatonin, Organoids