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P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway

Cell Cycle. 2021-08; 
Limei Yan, Zeping He, Wei Li, Ning Liu, Song Gao
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DNA Sequencing … In addition, the P76RBE overexpression vector (Ov-P76RBE) and control vector (Vector) were purchased from GenScript, Nanjing, China. Integrin β1 small interfering RNA (siRNA) and siNC were purchased from JTS scientific, Wuhan, China. The integrin β1 siRNA sequences … Get A Quote

摘要

Rhophilin Rho GTPase binding protein 2 (P76RBE) belongs to rhophilin family of Rho-GTPase-binding proteins and is found to contribute to the development of diverse cancers. Data in Oncomine and Kaplan-Meier Plotter databases showed that P76RBE was upregulated in ovarian cancer tissues compared with normal tissues, and patients with high P76RBE expression had worse overall survival, which indicated P76RBE may be associated with the pathogenesis of ovarian cancer. This study aimed to investigate the role of P76RBE in ovarian cancer and to reveal the possible underlying mechanisms. The results demonstrated that P76RBE was highly expressed in ovarian cancer tissues and ovarian cancer cell lines. Functionally, silen... More

关键词

P76RBE, integrin β1/NF-κB pathway, ovarian cancer