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Engineering Plant Sesquiterpene Synthesis into Yeasts: A Review

J Agric Food Chem. 2021-08; 
Jie Mai, Wenjuan Li, Rodrigo Ledesma-Amaro, Xiao-Jun Ji
Products/Services Used Details Operation
DNA Sequencing … lipolytica and procured as a synthetic construct from GenScript. The protein sequence of the … in pYLEX1 vector is described in the YLEX kit manual (Yeastern Biotech, Taipei, Taiwan). … & Industrial Strategy, Gov UK; Department of Biotechnology, Ministry of Science & Technology, … Get A Quote

摘要

Sesquiterpenes are natural compounds composed of three isoprene units. They represent the largest class of terpene compounds found in plants, and many have remarkable biological activities. Furthermore, sesquiterpenes have broad applications in the flavor, pharmaceutical and biofuel industries due to their complex structures. With the development of metabolic engineering and synthetic biology, the production of different sesquiterpenes has been realized in various chassis microbes. The microbial production of sesquiterpenes provides a promising alternative to plant extraction and chemical synthesis, enabling us to meet the increasing market demand. In this review, we summarized the heterologous production of di... More

关键词

Saccharomyces cerevisiae, Yarrowia lipolytica, metabolic engineering, sesquiterpene, synthetic biology