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A Defined Antigen Skin Test for Diagnosis of Bovine Tuberculosis in Domestic Water Buffaloes ()

Front Vet Sci. 2021-08; 
Tarun Kumar, Mahavir Singh, Babu Lal Jangir, Devan Arora, Sreenidhi Srinivasan, Devender Bidhan, Dipin Chander Yadav, Maroudam Veerasami, Douwe Bakker, Vivek Kapur, Naresh Jindal
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DNA Sequencing … Peptides (n = 13) representing these antigens were chemically synthesized at >98% purity by GenScript USA, Inc. and USV Private Limited, India (see Supplementary Table 1 for peptide sequences). The safety of DST has been demonstrated in Bos taurus subsp. … Get A Quote

摘要

Bovine tuberculosis (bTB) remains endemic in domestic water buffaloes () in India and elsewhere, with limited options for control other than testing and slaughter. The prescribed tuberculin skin tests with purified protein derivative (PPD) for diagnosis of bTB preclude the use of Bacille Calmette-Guérin (BCG)-based vaccination because of the antigenic cross-reactivity of vaccine strains with and related pathogenic members of the complex (MTBC). For the diagnosis of bTB in domestic water buffaloes, we here assessed a recently described defined-antigen skin test (DST) that comprises overlapping peptides representing the ESAT-6, CFP-10 and Rv3615c antigens, present in disease-causing members of the MTBC but mis... More

关键词

bovine tuberculosis, defined antigen skin test, sensitivity, specificity, water buffaloes (Bubalus bubalis)