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Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease

Int J Biol Macromol. 2021-08; 
Yunxia Xu, Ke Chen, Juanli Pan, Yingshou Lei, Danting Zhang, Lipei Fang, Jinle Tang, Xin Chen, Yanhong Ma, Yi Zheng, Bao Zhang, Yaoqi Zhou, Jian Zhan, Wei Xu
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DNA Sequencing … coding sequence was codon optimized and synthesized by Genscript Co.,Ltd. and cloned … sonication and the supernatant was centrifuged and loaded onto Ni-NTA resin (Genscript). … This fluorogenic peptide was synthesized and purified to a > 95% purity by GenScript. The … Get A Quote

摘要

COVID-19 is a disease caused by SARS-CoV-2, which has led to more than 4 million deaths worldwide. As a result, there is a worldwide effort to develop specific drugs for targeting COVID-19. Papain-like protease (PLpro) is an attractive drug target because it has multiple essential functions involved in processing viral proteins, including viral genome replication and removal of post-translational ubiquitination modifications. Here, we established two assays for screening PLpro inhibitors according to protease and anti-ISGylation activities, respectively. Application of the two screening techniques to the library of clinically approved drugs led to the discovery of tanshinone IIA sulfonate sodium and chloroxine ... More

关键词

Chloroxine, Papain-like protease, Tanshinone IIA sulfonate sodium