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Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein

ACS Pharmacol Transl Sci. 2021-07; 
Devivasha Bordoloi, Ziyang Xu, Michelle Ho, Mansi Purwar, Pratik Bhojnagarwala, Joel Cassel, Leila B Giron, Susanne Walker, Abhijeet J Kulkarni, Edgar Tello Ruiz, Jihae Choi, Faraz I Zaidi, Yuanhan Wu, Shaoying Wang, Ami Patel, Stephanie Ramos, Trevor Smith, Daniel Kulp, Kenneth E Ugen, Alagarsamy Srinivasan, Mohamed Abdel-Mohsen, Laurent Humeau, David B Weiner, Kar Muthumani
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Recombinant Antibody Expression … 2 (SARS-CoV-2), emerged in the city of Wuhan, China, and is currently causing a pandemic across the world.() In January 2020, the World … by intramuscular immunization followed by subcutaneous delivery of recombinant RBD protein (Genscript, USA) on day 28, as described.(,… Get A Quote

摘要

Coronavirus disease 2019 (COVID-19) is caused by the newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the highly contagious nature of SARS-CoV-2, it has infected more than 137 million individuals and caused more than 2.9 million deaths globally as of April 13, 2021. There is an urgent need to develop effective novel therapeutic strategies to treat or prevent this infection. Toward this goal, we focused on the development of monoclonal antibodies (mAbs) directed against the SARS-CoV-2 spike glycoprotein (SARS-CoV-2 Spike) present on the surface of virus particles as well as virus-infected cells. We isolated anti-SARS-CoV-2 Spike mAbs from animals immunized wit... More

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