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Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report

Cold Spring Harb Mol Case Stud. 2019-04; 
Elena V Poddubskaya, Madina P Baranova, Daria O Allina, Marina I Sekacheva, Lyudmila A Makovskaia, Dmitriy E Kamashev, Maria V Suntsova, Viktoria S Barbara, Irina N Kochergina-Nikitskaya, Alexey A Aleshin
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Oligo pool … Sequencing coverage table is available in Supplemental Table S4. Mutation calling was performed using the Picard and Genome Analysis Toolkit. The gene expression profile in the mixed sample was analyzed using the microarray platform CustomArray Inc (USA) … Get A Quote

摘要

Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despite multiple lines of therapy who underwent salvage therapy selection based on a novel bioinformatical decision support tool (Oncobox). This analysis generated a list of potentially actionable compounds, which when used clinically lead to partial response and later long-term stabilization of the patient's disease.

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