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Toxicity of gabapentin-lactam on the early developmental stage of zebrafish (Danio rerio)

Environ Pollut. 2021-06; 
Yide He, Dantong Jia, Sen Du, Rongwen Zhu, Wei Zhou, Shunlong Pan, Yongjun Zhang
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Molecular Biology Tools … Parental zebrafish (Tübingen line, 6 month-old, Danio rerio) were provided by Nanjing EzeRinka Biotech Company and maintained at 28 ± 0.5 °C, with … based on tool NCBI primer blast (https://www.ncbi.nlm.nih.gov/tools/primer-blast/), and synthesized by GenScript (Nanjing) Co … Get A Quote

摘要

Gabapentin-lactam (GBP-L) is a transformation product (TP) of gabapentin (GBP), a widely used anti-epileptic pharmaceutical. Due to its high persistence, GBP-L has been frequently detected in the surface water. However, the effects of GBP-L on aquatic organisms have not been thoroughly investigated. In the present study, zebrafish (Danio rerio) embryos as a model organism were used to study the impacts of GBP-L in terms of embryos LC, spontaneous movement at 24 hpf (hours post fertilization), heartbeat rates at 48 hpf, and body length at 72 hpf, with the concentrations of GBP-L down to 0.01 μg/L, covering its environmental concentrations. Various biomarkers from nervous, antioxidant and immune systems of zebr... More

关键词

Aquatic organism, Developmental toxicity, Environmental concentration, Gabapentin-lactum, Transformation product