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Cross-Reactive anti-Nucleocapsid Protein Immunity against Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus in Multiple Species

J Virol. 2021-01; 
Merve Kalkan-Yazıcı, Elif Karaaslan, Nesibe Selma Çetin, Sevde Hasanoğlu, Filiz Güney, Ümit Zeybek, Mehmet Z Doymaz
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Bacterial Expression … For CCHFV NP production, the nucleotide sequence of CCHFV Kelkit06 NP (1,449 bp) retrieved from GenBank (accession no. GQ337053) was optimized for bacterial expression, synthesized, and cloned into pUC19 (GenScript USA Inc., Nanjing, China) … Get A Quote

摘要

The World Health Organization estimates that there may be three billion people at risk of infection by Crimean-Congo Hemorrhagic Fever Virus (CCHFV), a highly lethal, emerging carried by ticks. On the other hand, the closely related Hazara virus (HAZV), a member of the same serogroup, has not been reported as a pathogen for humans. Given the structural and phylogenetic similarities between these two viruses, we evaluated the immunological similarities of the nucleocapsid protein (NP) of these two viruses in multiple species. Strong antigenic similarities were demonstrated in anti-NP humoral immune responses against HAZV and CCHFV in multiple species using convalescent human CCHF sera, rabbit and mouse polyclon... More

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