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IL-10 receptor blockade controls the in vitro infectivity of Leishmania infantum and promotes a Th1 activation in PBMC of dogs with visceral leishmaniasis

Mol Immunol. 2021-06; 
Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes de Brito, Ana Flávia Pereira Costa, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, João Filipe Pereira Vieira, Rodrigo Dian de Oliveira Aguiar Soares, Alexandre Barbosa Reis, Bruno Mendes Roatt
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Monoclonal Antibody Services … 2. Materials and methods. 2.1. Anti-canine IL-10 receptor-blocking monoclonal antibodies (Bloq 1 and 2). The canine antibodies anti alpha (Bloq 1/α-chain) and beta (Bloq 2/β-chain) subunit interleukin 10 receptor (Bloq IL-10R) were synthesized by GenScript USA Inc … Get A Quote

摘要

An important strategy to reduce the risk of visceral leishmaniasis (VL) in humans is to control the infection and disease progression in dogs, the domestic reservoir of Leishmania infantum parasites. Certain therapeutic strategies that modulate the host immune response show great potential for the treatment of experimental VL, restoring the impaired effector functions or decreasing host excessive responses. It is known that the overproduction of interleukin-10 (IL-10) promotes parasite replication and disease progression in human VL as well as in canine visceral leishmaniasis (CVL). Thus, in the present study we investigated the potential of the anti-canine IL-10 receptor-blocking monoclonal antibody (Bloq IL-1... More

关键词

Anti-canine IL-10 receptor-blocking monoclonal antibody, Canine visceral leishmaniasis, IL-10, Immunotherapy, Leishmania infantum