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Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity

Front Immunol. 2022-09; 
Arne Søraas, Gunnveig Grødeland, Beathe Kiland Granerud, Thor Ueland, Andreas Lind, Børre Fevang, Sarah L Murphy, Camilla Huse, Anders Benteson Nygaard, Anne Katrine Steffensen, Huda Al-Baldawi, Mona Holberg-Petersen, Lise Lima Andresen, Camilla Ågnes, Trine Ranheim, Ylva Schanke, Mette Istre, John Arne Dahl, Adity Chopra, Susanne Dudman, Mari Kaarbø, Jan Terje Andersen, Eline Benno Vaage, Trung The Tran, John Torgils Vaage, Annika E Michelsen, Fredrik Müller, Pål Aukrust, Bente Halvorsen, Tuva B Dahl, Jan Cato Holter, Fridtjof Lund-Johansen
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Catalog Peptides … coronaviruses were provided by Ulrich Rothbauer (University of Tuebingen) while linear peptides detected as common antigens in phage display were custom-ordered from Genscript (… Get A Quote

摘要

background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals. methods: We measured inflammatory mediators, antibodies to the SARS-CoV-2 spike and nucleocapsid proteins, and spike peptide-induced release of interferon gamma in whole blood in 51 double-vaccinated individuals infected with Omicron, in 14 infected with Delta, and in 18 healthy controls. The median time points for the first and second samples were 7 and 14 days after symptom onset, res... More

关键词

Breakthrough infection, SARS-CoV-2, antibody, cellular immunity, human, vaccine