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Mitochondrial micropeptide STMP1 promotes G1/S transition by enhancing mitochondrial complex IV activity

Mol Ther. 2022-04; 
Ye Sang, Jin-Yu Liu, Feng-Yi Wang, Xiao-Yu Luo, Zi-Qi Chen, Shi-Mei Zhuang, Ying Zhu
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Polyclonal Antibody Services … A custom polyclonal antibody against the C-terminal of STMP1 was generated by GenScript (Nanjing, China). Briefly, the C-terminal peptide (IKKDLDAKKKPPSA) of STMP1 was … Get A Quote

摘要

The roles of micropeptides in cell cycle regulation and cancer development remain largely unknown. Here we found that a micropeptide STMP1 (small transmembrane protein 1) was up-regulated in multiple malignancies including hepatocellular carcinoma (HCC), and its high level was associated with short recurrence-free survival of HCC patients. Gain- and loss-of-function analyses revealed that STMP1 accelerated cell proliferation and clonogenicity in vitro and tumor growth in vivo, and silencing STMP1 blocked G1/S transition. Mechanistically, STMP1 promoted the mRNA and protein levels of CCNE2, CDK2, and E2F1. STMP1 was localized in the inner membrane of mitochondria and interacted with mitochondrial complex IV an... More

关键词

G1/S transition, HCC, STMP1, micropeptide, mitochondria