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Streptococcus mutans glutamate binding protein (GlnH) as antigen target for a mucosal anti-caries vaccine

Braz J Microbiol. 2022-09; 
Gisela de Souza Pereira, Milene Tavares Batista, Nayara Fernanda Barros Dos Santos, Hélic Moreira Passos, Dalva Adelina da Silva, Ewerton Lucena Ferreira, Luís Carlos de Souza Ferreira, Rita de Cássia Café Ferreira
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GenParts™ DNA Fragments … The fragment derived from the glnH gene was synthesized by GenScript ( Piscataway, NJ, USA) based on the original gene sequence of the S. mutans UA159 strain and with codon … Get A Quote

摘要

background: In recent years, several studies have demonstrated that bacterial ABC transporters present relevant antigen targets for the development of vaccines against bacteria such as Streptococcus pneumoniae and Enterococcus faecalis. In Streptococcus mutans, the glutamate transporter operon (glnH), encoding an ABC transporter, is associated with acid tolerance and represents an important virulence-associated factor for the development of dental caries. results: In this study, we generated a recombinant form of the S. mutans GlnH protein (rGlnH) in Bacillus subtilis. Mice immunized with this protein antigen elicited strong antigen-specific antibody responses after sublingual administration of a vaccine formul... More

关键词

ABC transporters, Anti-caries vaccines, Dental caries, GlnH, LTK63, Mucosal adjuvant, Streptococcus mutans