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Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Invasive Infection

Int J Mol Sci. 2021-06; 
Jonothan Rosario-Colon, Karen Eberle, Abby Adams, Evan Courville, Hong Xin
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ORF cDNA Clones/MolecularCloud sterile filtered in phosphate-buffered saline (PBS) by GenScript Biotech Corporation (GenScript, Piscataway, NJ, USA) Get A Quote

摘要

is a multidrug-resistant fungal pathogen that can cause disseminated bloodstream infections with up to 60% mortality in susceptible populations. Of the three major classes of antifungal drugs, most isolates show high resistance to azoles and polyenes, with some clinical isolates showing resistance to all three drug classes. We reported in this study a novel approach to treating disseminated infections through passive transfer of monoclonal antibodies (mAbs) targeting cell surface antigens with high homology in medically important species. Using an established A/J mouse model of disseminated infection that mimics human candidiasis, we showed that C3.1, a mAb that targets β-1,2-mannotriose (β-Man), significa... More

关键词

C. auris, candidiasis, cell wall, monoclonal antibodies, multidrug resistance, passive immunization, universal antibodies