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Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression

Neuropsychiatr Dis Treat. 2021-08; 
Ling Zhang, Lei Zhang, Rubo Sui
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Custom DNA/RNA Oligos … The specific primers were designed by GenScript (Nanjing, China), and the sequences were shown as follows: TNF-α (Forward: 5ʹ-ACTGAACTTCGGGGTGATCG-3ʹ, Reverse: 5ʹ … Get A Quote

摘要

background: Post-stroke depression (PSD) is a common complication after stroke. Ganoderic acid A (GAA), one of the main bioactive Ganoderma triterpenoids, exerts preventive and therapeutic effects in many diseases. However, the function of GAA in PSD has not been well studied. methods: PSD model was established via stimulating rats with chronic unpredictable mild stress stimulations (CUMS) after middle cerebral artery occlusion (MCAO). Rats were treated with GAA before CUMS. Depressive-like behaviors were investigated by body weight alteration, open field test (OFT), and sucrose preference test (SPT). Neuronal damage was evaluated by hematoxylin and eosin (HE) staining and Western blotting. Inflammation was det... More

关键词

extracellular signal-regulated kinase, ganoderic acid A, inflammation, microglial polarization, neuronal damage, post-stroke depression