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Dysregulation of Ki-67 Expression in T Cells of Children with Autism Spectrum Disorder

Children (Basel). 2021-02; 
Khaled Alhosaini, Mushtaq A Ansari, Ahmed Nadeem, Sabry M Attia, Saleh A Bakheet, Laila Y Al-Ayadhi, Hafiz M Mahmood, Haneen A Al-Mazroua, Sheikh F Ahmad
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Custom DNA/RNA Oligos … purchased from Applied Biosystems (Foster City, CA, USA). Primers were synthesized from GenScript (Piscataway, NJ, USA). 2.5. Flow Cytometric Analysis … Get A Quote

摘要

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral abnormalities such as impairments in social function and deficits in communication. The etiology of autism is unknown in most cases, but many studies have pointed towards the immune system as a causative agent in autism. Specific studies implicated lymphocytes, natural killer (NK) cells, monocytes, cytokines, and specific transcription factors in the development of ASD. The protein Ki-67 is n expressed in the proliferating cells and is used as a tool in several disorders. Ki-67 plays a crucial role in many neurological diseases. However, Ki-67 role in ASD is not fully understood. In this study, we investigated the possib... More

关键词

Ki-67, autism spectrum disorder, inflammatory mediators, peripheral blood mononuclear cells, typically developing control