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Upregulated Tie2 expression in plasma: a potential non-invasive biomarker for the diagnosis of breast cancer

Eur Cytokine Netw. 2021-06; 
Qingzhu Song, Fenglan Zhang, Tian Yuan, Yulong Wei
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Molecular Biology Tools … Three siRNAs against Tie were designed using siRNA design tool of GeneScript (https://www.genscript.com/ tools/sirna-target-finder) and their sequences were … Get A Quote

摘要

Breast cancer is by far the most common malignancy found in women and causes a significant public health problem around the world. Early diagnosis of cancer plays an important role in successful treatment and survival of patients. This study aims to investigate the possibility of plasma Tie2 to be used as a biomarker for diagnosis of breast cancer. In total, 20 healthy volunteers and 33 breast cancer patients were considered for this study. The level of Tie2 in plasma was detected using the ELISA technique and immunohistochemistry was performed to measure the expression of Tie2 in normal and breast cancer tissues. Plasma concentrations of Tie2 were significantly higher among breast cancer patients compared to h... More

关键词

Tie2, biomarker, breast cancer, non-invasive diagnosis, plasma