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Design of a chitosan-based nano vaccine against epsilon toxin of type D and evaluation of its immunogenicity in BALB/c mice

Res Pharm Sci. 2021-10; 
Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi
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Bacterial Expression … The codons of the ETX were optimized by the GenScript service (http://www.genscript.com/ gene_synthesis.html), based on the codon usage table of E. coli for the back-translation of the … Get A Quote

摘要

objective: is an anaerobic, spore-forming, and pathogenic bacterium that causes intestinal diseases in humans and animals. In these cases, therapeutic intervention is challenging; because the disease progresses much rapidly. This bacterium can produce 5 main toxins (alpha, beta, epsilon, iota, and a type of enterotoxin) among which the epsilon toxin (ETX) is used for bioterrorism. This toxin can be prevented by immunization with specific immunogenic vaccines. In the present research, we aimed at developing a recombinant chitosan-based nano-vaccine against ETX of and evaluate its effects on the antibody titration against epsilon toxin in BALB/c mice as the vaccine model. methods: The gene from type D was clon... More

关键词

Chitosan, Clostridium perfringens, Epsilon toxin, Immunization, Nano-vaccine