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GenParts™ DNA Fragments> | … In this technical report, we present a mouse model that enables us to investigate the role and … A 7-kb DNA fragment was synthesized by GenScript, containing a 3,225-bp mouse p21 … | Get A Quote |
The role of senescent cells has been implicated in various tissue dysfunction associated with aging, obesity, and other pathological conditions. Currently, most transgenic mouse models only target -highly-expressing ( ) cells. Here, we generated a -Cre mouse model, containing a promoter driving inducible Cre, enabling us to examine -highly-expressing ( ) cells, a previously unexplored cell population exhibiting several characteristics typical of senescent cells. By crossing -Cre mice with different floxed mice, we managed to monitor, sort, image, eliminate, or modulate cells . We showed cells can be induced by various conditions, and percentages of cells varied from 1.5 to 10% across different tissues ... More