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Quercetin alleviates acute kidney injury by inhibiting ferroptosis

J Adv Res. 2020-07; 
Yue Wang, Fei Quan, Qiuhua Cao, Yanting Lin, Chongxiu Yue, Ran Bi, Xinmeng Cui, Hongbao Yang, Yong Yang, Lutz Birnbaumer, Xianjing Li, Xinghua Gao
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Custom DNA/RNA Oligos … All primers were custom-made by Genscript. The primer sequences are shown in … , we knocked down the expression of ATF3 with siRNA, and the knockdown efficiency was confirmed … Get A Quote

摘要

background: Ferroptosis is an iron-dependent regulated necrosis and has been proven to contribute to the progress of acute kidney injury (AKI). Quercetin (QCT), a natural flavonoid which is commonly found in numerous fruits and vegetables, has extensive pharmacological effects, such as anti-oxidant, anti-inflammatory and anti-senescence effects. objective: This study aims to explain whether ferroptosis is a therapeutic strategy to AKI, and to explore the effect of QCT on AKI ferroptosis. methods: NRK-52E cells and HK-2 cells were used for in vitro ferroptosis studies. Morphology of cells was detected by transmission electron microscopy. Lipid ROS was assayed using flow cytometry. In vivo, AKI was induced by isc... More

关键词

Activation transcription factor 3, Acute kidney injury, Ferroptosis, Macrophages, Quercetin