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Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia

J Immunother Cancer. 2021-09; 
Weiyi Wang, Shuaitong Liu, Peihong Dai, Ning Yang, Yi Wang, Rachel A Giese, Taha Merghoub, Jedd Wolchok, Liang Deng
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Recombinant Antibody Expression  DNAse I and Liberase TL were purchased from Roche. Recombinant murine GM-CSF protein was purchased from GenScript Get A Quote

摘要

background: Viral-based immunotherapy can overcome resistance to immune checkpoint blockade (ICB) and fill the unmet needs of many patients with cancer. Oncolytic viruses (OVs) are defined as engineered or naturally occurring viruses that selectively replicate in and kill cancer cells. OVs also induce antitumor immunity. The purpose of this study was to compare the antitumor effects of live oncolytic vaccinia viruses versus the inactivated versions and elucidate their underlying immunological mechanisms. methods: We engineered a replication-competent, oncolytic vaccinia virus (OV-GM) by inserting a murine GM-CSF gene into the thymidine kinase locus of a mutant vaccinia E3L∆83N, which lacks the Z-DNA-binding d... More

关键词

dendritic cells, immunotherapy, interferon inducers, oncolytic virotherapy, tumor microenvironment