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BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease

Cell Death Discov. 2021-03; 
Xiaoqing Zhang, Juan Li, Li Ma, Hui Xu, Yun Cao, Wei Liang, Jia Ma, Z Peter Wang, Yuyun Li
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摘要

Alzheimer's disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins. Evidence has demonstrated that bone morphogenetic protein 4 (BMP4) is highly expressed in transgenic mouse models of AD and that endogenous levels of BMP4 mainly affect hippocampal function. To determine whether BMP4 participates in AD development, transgenic mice were constructed that overexpress BMP4 under the control of the neuron-specific enolase (NSE) promoter. We also performed MTT, FACS, transfection, TUNEL, and Western blotting assays to define the role of BMP4 in cells. We found that middle-age... More

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