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Collapsin response mediator protein 5 (CRMP5) modulates susceptibility to chronic social defeat stress in mice

Mol Neurobiol. 2021-02; 
Yu-Fen Lin, Kao Chin Chen, Yen Kuang Yang, Ya-Hsin Hsiao
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ORF cDNA Clones/MolecularCloud the mouse Dpysl5 cDNA open reading frame (ORF) clone (NM_023047.2) was purchased from GenScript (Piscataway, NJ, USA). Get A Quote

摘要

Collapsin response mediator protein 5 (CRMP5), a member of the CRMP family, is expressed in the brain, particularly in the hippocampus, an area of the brain that can modulate stress responses. Social stress has a well-known detrimental effect on health and can lead to depression, but not all individuals are equally sensitive to stress. To date, researchers have not conclusively determined how social stress increases the susceptibility of the brain to depression. Here, we used the chronic social defeat stress (CSDS) model and observed higher hippocampal CRMP5 expression in stress-susceptible (SS) mice than in control and stress-resilient (RES) mice. A negative correlation was observed between the expression leve... More

关键词

CRMP5, Chronic social defeat stress, Corticosterone, Susceptibility