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A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc

Oncol Lett. 2021-08; 
Fei Leng, Yan-Yu Miu, Yi Zhang, Hao Luo, Xiao-Li Lu, Hui Cheng, Zhi-Guo Zheng
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Custom RNAi Services … divided into 2 groups according to the mean mRNA expression (3.56) and Kaplan-Meier … To establish a stable cell line, lentivirus was obtained from GenScript, and the following short … Get A Quote

摘要

HOXB-AS3 is a long non-coding RNA and recent studies have shown that the HOXB-AS3-encoded micro-peptide was associated with the progression of colon cancer tumorigenesis; however, the biofunction of HOXB-AS3 varies in different types of cancer and the potential function in oral squamous cell carcinoma (OSCC) is still unknown. The Cancer Genome Atlas (TCGA) database was searched and the expression patterns of HOXB-AS3 in head and neck carcinoma were analyzed. Reverse transcription-quantitative PCR and western blot analysis was used to measure the mRNA and protein expression level of HOXB-AS3 in patients with OSCC, respectively. Next, HOXB-AS3 was knocked down in 2 OSCC cell lines to investigate the biological fu... More

关键词

HOXB-AS3, IGF2BP2, OSCC, c-Myc, lncRNA, proliferation