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Spatiotemporal coordination of antigen presentation and co-stimulatory signal for enhanced anti-tumor vaccination

Journal of controlled release. 2024-08; 
Sha Peng , Yumeng Yan , Kenji Ogino , Guanghui Ma , Yufei Xia
Products/Services Used Details Operation
Peptoid Synthesis All antigenic short peptides were synthesized by GenScript Biotech Corporation. Ghost Dye-Violet 450, Ghost Dye-Violet 510, FITC-CD11c, APC-CD86, PE-Cy7-CD86, PE-SIINFEKL/H-2Kb, APCCCR7, APC-Cy7-CD3e, V450-CD3e, Per-CP5.5-CD8a, and PE-Fas were purchased from Tonbo Biosciences Get A Quote

摘要

Controlled-release systems enhance anti-tumor effects by leveraging local antigen persistence for antigen-presenting cells (APCs) recruitment and T cell engagement. However, constant antigen presentation alone tends to induce dysfunction in tumor-specific CD8+ T cells, neglecting the synergistic effects of co-stimulatory signal. To address this, we developed a soft particle-stabilized emulsion (SPE) to deliver lipopeptides with controlled release profiles by adjusting their hydrophobic chain lengths: C6-SPE (fast release), C10-SPE (medium release), and C16-SPE (slow release). Following administration, C6-SPE release antigen rapidly, inducing early antigen presentation, whereas C16-SPE's slow-release delays anti... More

关键词

Co-stimulatory molecule; Cross-presentation; Lipopeptides; Pickering emulsions; Sequential delivery.