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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
Authors: Tsz-Yin Chan, Christina M Egbert, Julia E Maxson, Adam Siddiqui, Logan J Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L Pennington, Tsz-Ming Tsang, Madison Frey, Erik J Soderblom, Huimin Geng, Markus Müschen, Tetyana V Forostyan, Savannah Free, Gaelle Mercenne, Courtney J Banks, Jonard Valdoz, Clifford J Whatcott, Jason M Foulks, David J Bearss, Thomas O'Hare, David C S Huang, Kenneth A Christensen, James Moody, Steven L Warner, Jeffrey W Tyner, Joshua L Andersen
Journal: Nat Commun
PubMed ID: 34504101
Doi: 10.1038/s41467-021-25622-3
Products & Services: Mutagenesis Services   
Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies
Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver
Journal: Am J Med Genet A
PubMed ID: 34523780
Doi: 10.1002/ajmg.a.62497
Products & Services: Mutagenesis Services   
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response
Authors: Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham
Journal: J Clin Invest
PubMed ID: 34623328
Doi: 10.1172/JCI145472
Products & Services: Mutagenesis Services   
Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity
Authors: Ashley C Dougherty, Mariam G Hawaz, Kristine G Hoang, Judy Trac, Jacob M Keck, Carmen Ayes, Joseph E Deweese
Journal: ACS Omega
PubMed ID: 34660952
Doi: 10.1021/acsomega.1c02083
Products & Services: Mutagenesis Services   
The DNA Recognition Motif of GapR Has an Intrinsic DNA Binding Preference towards AT-rich DNA
Authors: Qian Huang, Bo Duan, Zhi Qu, Shilong Fan, Bin Xia
Journal: Molecules
PubMed ID: 34641320
Doi: 10.3390/molecules26195776
Products & Services: Mutagenesis Services   
A Secreted Chorismate Mutase from pv Attenuates Virulence and Walnut Blight Symptoms
Authors: Renata de A B Assis, Cíntia H D Sagawa, Paulo A Zaini, Houston J Saxe, Phillip A Wilmarth, Brett S Phinney, Michelle Salemi, Leandro M Moreira, Abhaya M Dandekar
Journal: Int J Mol Sci
PubMed ID: 34638715
Doi: 10.3390/ijms221910374
Products & Services: Mutagenesis Services   
Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
Authors: Juan Luis Pacheco-Garcia, Ernesto Anoz-Carbonell, Pavla Vankova, Adithi Kannan, Rogelio Palomino-Morales, Noel Mesa-Torres, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey
Journal: Redox Biol
PubMed ID: 34537677
Doi: 10.1016/j.redox.2021.102112
Products & Services: Mutagenesis Services   
Human Cystathionine γ-Lyase Is Inhibited by -Nitrosation: A New Crosstalk Mechanism between NO and HS
Authors: Dalila G F Fernandes, João Nunes, Catarina S Tomé, Karim Zuhra, João M F Costa, Alexandra M M Antunes, Alessandro Giuffrè, João B Vicente
Journal: Antioxidants (Basel)
PubMed ID: 34573023
Doi: 10.3390/antiox10091391
Products & Services: Mutagenesis Services   
Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3
Authors: Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan
Journal: Viruses
PubMed ID: 34452398
Doi: 10.3390/v13081533
Products & Services: Mutagenesis Services   
MicroRNA-138 Increases Chemo-Sensitivity of Glioblastoma through Downregulation of Survivin
Authors: Ji-Young Yoo, Margaret Yeh, Yin-Ying Wang, Christina Oh, Zhong-Ming Zhao, Balveen Kaur, Tae-Jin Lee
Journal: Biomedicines
PubMed ID: 34356844
Doi: 10.3390/biomedicines9070780
Products & Services: Mutagenesis Services   

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