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Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity
Authors: Razan Orfali, Young-Woo Nam, Hai Minh Nguyen, Mohammad Asikur Rahman, Grace Yang, Meng Cui, Heike Wulff, Miao Zhang
Journal: Cell Calcium
Doi: doi.org/10.1016/j.ceca.2022.102538
Products & Services: Mutagenesis Services   
A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control
Authors: Griffin M Schroeder, Chapin E Cavender , Maya E Blau, Jermaine L Jenkins, David H Mathews, Joseph E Wedekind
Journal: Nat Commun
PubMed ID: 35017488
Doi: 10.1038/s41467-021-27790-8
Products & Services: Mutagenesis Services   PCR Cloning and Subcloning   
Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies
Authors: Jeong A Park, Nai-Kong V Cheung
Journal: J Immunother Cancer
PubMed ID: 35086947
Doi: 10.1136/jitc-2021-003771
Products & Services: Mutagenesis Services   
pVHL-mediated SMAD3 degradation suppresses TGF-β signaling
Authors: Jun Zhou , Yasamin Dabiri , Rodrigo A Gama-Brambila, Shahrouz Ghafoory , Mukaddes Altinbay , Arianeb Mehrabi , Mohammad Golriz , Biljana Blagojevic , Stefanie Reuter , Kang Han , Anna Seidel , Ivan Đikić , Stefan Wölfl , Xinlai Cheng
Journal: J Cell Biol
PubMed ID: 34860252
Doi: 10.1083/jcb.202012097
Products & Services: ORF cDNA Clones/MolecularCloud   Mutagenesis Services   Gene Synthesis   
Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3
Authors: Chad S Hewitt, Chittaranjan Das, Daniel P Flaherty
Journal: Biomolecules
PubMed ID: 35053210
Doi: 10.3390/biom12010062
Products & Services: Mutagenesis Services   
Mesenchymal Stem/Stromal Cells Overexpressing CXCR4 Revealed Enhanced Migration: A Lesson Learned from the Pathogenesis of WHIM Syndrome
Authors: Hamid Reza Bidkhori, Ahmad Reza Bahrami, Moein Farshchian, Asieh Heirani-Tabasi, Mahdi Mirahmadi, Halimeh Hasanzadeh, Naghmeh Ahmadiankia, Reza Faridhosseini, Mahtab Dastpak, Arezoo Gowhari Shabgah, Maryam M Matin
Journal: Cell Transplant
PubMed ID: 34807749
Doi: 10.1177/09636897211054498
Products & Services: Mutagenesis Services   
Engineered Sphingomonas sp KT-1 PahZ1 monomers efficiently degrade poly(aspartic acid)
Authors: Timothy Lamantia, Amanda Jansch, Justin D Marsee, Mitch H Weiland, Justin M Miller
Journal: Biophys Chem
PubMed ID: 34953381
Doi: 10.1016/j.bpc.2021.106745
Products & Services: Mutagenesis Services   
Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers
Authors: Lise L Holm, Thomas K Doktor, Michael B Hansen, Ulrika S S Petersen, Brage S Andresen
Journal: Hum Mutat
PubMed ID: 34923709
Doi: 10.1002/humu.24321
Products & Services: Mutagenesis Services   
SAF-A mutants disrupt chromatin structure through dominant negative effects on RNAs associated with chromatin
Authors: Heather J Kolpa, Kevin M Creamer, Lisa L Hall, Jeanne B Lawrence
Journal: Mamm Genome
PubMed ID: 34859278
Doi: 10.1007/s00335-021-09935-8
Products & Services: Mutagenesis Services   
Engineered Sphingomonas sp KT-1 PahZ1 monomers efficiently degrade poly(aspartic acid)
Authors: Timothy Lamantia, Amanda Jansch, Justin D Marsee, Mitch H Weiland, Justin M Miller
Journal: Biophys Chem
PubMed ID: 34953381
Doi: 10.1016/j.bpc.2021.106745
Products & Services: Mutagenesis Services   

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