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Restoration of Sarco/Endoplasmic Reticulum Ca-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca Depletion
Authors: Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin
Journal: Front Pharmacol
PubMed ID: 35517826
Doi: 10.3389/fphar.2022.877175
Products & Services: Mutagenesis Services   
Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding
Authors: Nathan L Ponzar, Razia Tajwar, Nicola Pozzi, John E Tavis
Journal: J Biol Chem
PubMed ID: 35247386
Doi: 10.1016/j.jbc.2022.101790
Products & Services: Mutagenesis Services   
Glutathione binding to the plant Atm3 transporter and implications for the conformational coupling of ABC transporters
Authors: Chengcheng Fan, Douglas C Rees
Journal: Elife
PubMed ID: 35333177
Doi: 10.7554/eLife.76140
Products & Services: Mutagenesis Services   
Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation
Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher
Journal: Front Immunol
PubMed ID: 35222427
Doi: 10.3389/fimmu.2022.836549
Products & Services: Mutagenesis Services   
Ligand-directed bias of G protein signaling at the dopamine D2 receptor
Authors: Ee Von Moo , Kasper Harpsøe , Alexander S Hauser , Ikuo Masuho , Hans Bräuner-Osborne , David E Gloriam , Kirill A Martemyanov
Journal: Cell Chem Biol .
PubMed ID: 34302750
Doi: 10.1016/j.chembiol.2021.07.004
Products & Services: Mutagenesis Services   Gene Synthesis   
Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation
Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher
Journal: Front Immunol
PubMed ID: 35222427
Doi: 10.3389/fimmu.2022.836549
Products & Services: Mutagenesis Services   
Channelopathy-causing mutations in the SA/SB and HA/HB helices of K23 and K31 channels alter their apparent Ca sensitivity
Authors: Razan Orfali, Young-Woo Nam, Hai Minh Nguyen, Mohammad Asikur Rahman, Grace Yang, Meng Cui, Heike Wulff, Miao Zhang
Journal: Cell Calcium
PubMed ID: 35030515
Doi: 10.1016/j.ceca.2022.102538
Products & Services: Mutagenesis Services   
Mapping Critical Residues in ATG11's Coiled-Coil 2 Domain that Block Multiple Interactions and Disrupt Selective Autophagy
Authors: Mitchell D Meyer, Jasmine Winzeler, Sophia M Taylor, Alex Kilgore, Kimberly Edicha, Chase Chitwood, Zachary Spearin, S K Nadia Rahman Silvia, Ronith Chakraborty, Jesse E Smith, Bridget Kennedy, Carson Zois, Hayley Cawthon, Mukiri Gilruth, Steven K Backues
Journal: Front Cell Dev Biol
PubMed ID: 35118068
Doi: 10.3389/fcell.2021.775364
Products & Services: Mutagenesis Services   
Vps501, a novel vacuolar SNX-BAR protein cooperates with the SEA complex to regulate TORC1 signaling
Authors: Shreya Goyal, Verónica A Segarra, Aaron M Stetcher, Andrew W Truman, Adam M Reitzel, Richard J Chi
Journal: Traffic
PubMed ID: 35098628
Doi: 10.1111/tra.12833
Products & Services: Mutagenesis Services   
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life
Authors: Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen
Journal: iScience
PubMed ID: 35118359
Doi: 10.1016/j.isci.2022.103746
Products & Services: Mutagenesis Services   

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