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A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships
Authors: Taylor L Mighell, Sara Evans-Dutson, Brian J O'Roak
Journal: Am J Hum Genet
PubMed ID: 29706350
Doi: 10.1016/j.ajhg.2018.03.018
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Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
Authors: Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE
Journal: Nature Genetics
PubMed ID: 29379199
Doi: 10.1038/s41588-018-0044-9
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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
Authors: Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE
Journal: Nature Chemical Biology
PubMed ID: 29507391
Doi: 10.1038/s41589-018-0010-y
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Highly selective retrieval of accurate DNA utilizing a pool of in situ-replicated DNA from multiple next-generation sequencing platforms
Authors: Lim H, Cho N, Ahn J, Park S, Jang H, Kim H, Han H, Lee JH, Bang D
Journal: Nucleic Acids Research
PubMed ID: 29361040
Doi: 10.1093/nar/gky016
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Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection
Authors: Heon Seok Kim, Kyungjin Lee, Seong-Jun Kim, Sungchan Cho, Hye Jin Shin, Chonsaeng Kim, Jin-Soo Kim
Journal: Genome Res
PubMed ID: 29712754
Doi: 10.1101/gr.230250.117
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SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data
Authors: Dotu I, Adamson SI, Coleman B, Fournier C, Ricart-Altimiras E, Eyras E, Chuang JH
Journal: PLoS computational biology
PubMed ID: 29596423
Doi: 10.1371/journal.pcbi.1006078
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Deep learning improves prediction of CRISPR-Cpf1 guide RNA activity
Authors: Kim HK, Min S, Song M, Jung S, Choi JW, Kim Y, Lee S, Yoon S, Kim HH
Journal: Nature Biotechnology
PubMed ID: 29431740
Doi: 10.1038/nbt.4061
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Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
Authors: Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R
Journal: Molecular Cell
PubMed ID: 29452640
Doi: 10.1016/j.molcel.2018.01.024
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Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
Authors: Neggers JE, Kwanten B, Dierckx T, Noguchi H, Voet A, Bral L, Minner K, Massant B, Kint N, Delforge M, Vercruysse T, Baloglu E, Senapedis W, Jacquemyn M, Daelemans D
Journal: Nature Communications
PubMed ID: 29402884
Doi: 10.1038/s41467-017-02349-8
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Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
Authors: Jeselsohn R, Bergholz JS, Pun M, Cornwell M, Liu W, Nardone A, Xiao T, Li W, Qiu X, Buchwalter G, Feiglin A, Abell-Hart K, Fei T, Rao P, Long H, Kwiatkowski N, Zhang T, Gray N, Melchers D, Houtman R, Liu XS, Cohen O, Wagle N, Winer EP, Zhao J, Brown M
Journal: Cancer Cell
PubMed ID: 29438694
Doi: 10.1016/j.ccell.2018.01.004
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