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AcrIF5 specifically targets DNA-bound CRISPR-Cas surveillance complex for inhibition

Authors: Yongchao Xie, Laixing Zhang, Zhengyu Gao, Peipei Yin, Hao Wang, Hang Li, Zeliang Chen, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nat Chem Biol

PubMed ID: 35301482

Doi: 10.1038/s41589-022-00995-8

Products & Services: PCR and Cloning

RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication

Authors: Alexis Brugier, Mohamed Lamine Hafirrassou, Marie Pourcelot, Morgane Baldaccini, Vasiliya Kril, Laurine Couture, Beate M Kümmerer, Sarah Gallois-Montbrun, Lucie Bonnet-Madin, Pierre-Olivier Vidalain, Constance Delaugerre, Sébastien Pfeffer, Laurent Meertens, Ali Amara

Journal: J Virol

PubMed ID: 35266803

Doi: 10.1128/jvi.01962-21

Products & Services: Mammalian Expression

OvoA from ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities

Authors: Ronghai Cheng, Andrew C Weitz, Jared Paris, Yijie Tang, Jingyu Zhang, Heng Song, Nathchar Naowarojna, Kelin Li, Lu Qiao, Juan Lopez, Mark W Grinstaff, Lixin Zhang, Yisong Guo, Sean Elliott, Pinghua Liu

Journal: Chem Sci

PubMed ID: 35432880

Doi: 10.1039/d1sc05479a

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miR-2055 regulates lipid metabolism via fatty acid synthase expression

Authors: Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zhen Zou

Journal: Open Biol

PubMed ID: 35232249

Doi: 10.1098/rsob.210307

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury

Authors: Zhao-Ying Ding, Tao-Tao Tang, Zuo-Lin Li, Jing-Yuan Cao, Lin-Li Lv, Yi Wen, Bin Wang, Bi-Cheng Liu

Journal: Kidney Dis (Basel)

PubMed ID: 35702708

Doi: 10.1159/000522584

Products & Services: Proteins, Expression, Isolation and Analysis

Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

Authors: Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C Fragoso, Brittany N Dugger, Paul F Wilson, Matthew A Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M Monjazeb, Aijun Wang, William J Murphy, Hsing-Jien Kung, Kit S Lam, Hong-Wu Chen, Jian Jian Li

Journal: Nat Commun

PubMed ID: 35314680

Doi: 10.1038/s41467-022-29137-3

Products & Services: Mammalian Expression

Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria

Authors: Huan Yang, Caroline Sibilla, Raymond Liu, Jina Yun, Bruce A Hay, Craig Blackstone, David C Chan, Robert J Harvey, Ming Guo

Journal: Nat Commun

PubMed ID: 35332133

Doi: 10.1038/s41467-022-29071-4

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes

Authors: Colin S McHugh, Paul D Cook

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 35400666

Doi: 10.1107/S2053230X22002400

Products & Services: Mutant Libraries

MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis

Authors: Lu Feng, Zhengmeng Yang, Yucong Li, Qi Pan, Xiaoting Zhang, Xiaomin Wu, Jessica Hiu Tung Lo, Haixing Wang, Shanshan Bai, Xuan Lu, Ming Wang, Sien Lin, Xiaohua Pan, Gang Li

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474736

Doi: 10.1016/j.omtn.2022.03.016

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Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury

Authors: Kurt Bachmaier, Andrew Stuart, Abhalaxmi Singh, Amitabha Mukhopadhyay, Sreeparna Chakraborty, Zhigang Hong, Li Wang, Yoshikazu Tsukasaki, Mark Maienschein-Cline, Balaji B Ganesh, Prasad Kanteti, Jalees Rehman, Asrar B Malik

Journal: ACS Nano

PubMed ID: 35230826

Doi: 10.1021/acsnano.1c09762

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Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Authors: Neha Singh, András Zeke, Attila Reményi

Journal: Int J Mol Sci

PubMed ID: 35328741

Doi: 10.3390/ijms23063320

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Method for quantification of porcine type I interferon activity using luminescence, by direct and indirect means

Authors: Michael Puckette, J Barrera, M Schwarz, M Rasmussen

Journal: BMC Biotechnol

PubMed ID: 35351081

Doi: 10.1186/s12896-022-00743-9

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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender

Journal: AIDS

PubMed ID: 35084382

Doi: 10.1097/QAD.0000000000003111

Products & Services: Endotoxin Detection & Removal System

Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cells

Authors: Marwa Arbi, Imen Larbi, Jihen Nsiri, Imen El Behi, Ahmed Rejeb, Khaled Miled, Adeljelil Ghram, Mehdi Houimel

Journal: Virus Res

PubMed ID: 35306102

Doi: 10.1016/j.virusres.2022.198745

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RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Authors: Qingtai Liang, Yifeng Wang, Shuyuan Zhang, Jing Sun, Wenbo Sun, Jizhou Li, Yaping Liu, Mingxi Li, Lin Cheng, Yuhang Jiang, Ruoke Wang, Rui Zhang, Zihan Yang, Yifei Ren, Peng Chen, Peng Gao, Huayuan Yan, Zheng Zhang, Qi Zhang, Xuanling Shi, Jianbin Wang, Wanli Liu, Xinquan Wang, Bo Ying, Jincun Zhao, Hai Qi, Linqi Zhang

Journal: iScience

PubMed ID: 35291264

Doi: 10.1016/j.isci.2022.104043

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DNA methylation in Friedreich ataxia silences expression of frataxin isoform E

Authors: Layne N Rodden, Kaitlyn M Gilliam, Christina Lam, Teerapat Rojsajjakul, Clementina Mesaros, Chiara Dionisi, Mark Pook, Massimo Pandolfo, David R Lynch, Ian A Blair, Sanjay I Bidichandani

Journal: Sci Rep

PubMed ID: 35322126

Doi: 10.1038/s41598-022-09002-5

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FSH blockade improves cognition in mice with Alzheimer's disease

Authors: Jing Xiong, Seong Su Kang, Zhihao Wang, Xia Liu, Tan-Chun Kuo, Funda Korkmaz, Ashley Padilla, Sari Miyashita, Pokman Chan, Zhaohui Zhang, Pavel Katsel, Jocoll Burgess, Anisa Gumerova, Kseniia Ievleva, Damini Sant, Shan-Ping Yu, Valeriia Muradova, Tal Frolinger, Daria Lizneva, Jameel Iqbal, Ki A Goosens, Sakshi Gera, Clifford J Rosen, Vahram Haroutunian, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye

Journal: Nature

PubMed ID: 35236988

Doi: 10.1038/s41586-022-04463-0

Products & Services: Gene Synthesis

Protein Electrostatics Investigated through Paramagnetic NMR for Nonpolar Groups

Authors: Binhan Yu, Channing C Pletka, Junji Iwahara

Journal: J Phys Chem B

PubMed ID: 35266708

Doi: 10.1021/acs.jpcb.1c10930

Products & Services: Mammalian Expression

Identifying Function Determining Residues in Neuroimmune Semaphorin 4A

Authors: Svetlana P Chapoval, Mariah Lee, Aaron Lemmer, Oluwaseyi Ajayi, Xiulan Qi, Andrew F Neuwald, Achsah D Keegan

Journal: Int J Mol Sci

PubMed ID: 35328445

Doi: 10.3390/ijms23063024

Products & Services: Mutant Libraries

Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2

Authors: Jun-Xue Jin, Jing-Tao Sun, Chao-Qian Jiang, Hong-Di Cui, Ya Bian, Sanghoon Lee, Lianjin Zhang, Byeong Chun Lee, Zhong-Hua Liu

Journal: Antioxidants (Basel)

PubMed ID: 35453372

Doi: 10.3390/antiox11040687

Products & Services: Proteins, Expression, Isolation and Analysis

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Authors: Zi-Wei Ye, Chon Phin Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, Runhong Zhou, Peng Luo, Yun Cheng, Victor Sebastien Gray, Pui Wang, Hin Chu, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Honglin Chen, Zhiwei Chen, Kwok-Yung Yuen, Guang Sheng Ling, Shuofeng Yuan, Dong-Yan Jin

Journal: Cell Mol Immunol

PubMed ID: 35352010

Doi: 10.1038/s41423-022-00855-4

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Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations

Authors: Samuel M Goodfellow, Robert A Nofchissey, Chunyan Ye, Jonathan L Dunnum, Joseph A Cook, Steven B Bradfute

Journal: Viruses

PubMed ID: 35458412

Doi: 10.3390/v14040682

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Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

Authors: Roberto Vázquez, Mateo Seoane-Blanco, Virginia Rivero-Buceta, Susana Ruiz, Mark J van Raaij, Pedro García

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35362467

Doi: 10.1107/S2059798322000936

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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

Authors: Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu

Journal: Cell Rep

PubMed ID: 35320710

Doi: 10.1016/j.celrep.2022.110538

Products & Services: Plasmid DNA Preparation

An ArsRC fusion protein enhances arsenate sensing and detoxification

Authors: Jian Chen, Adriana E Galván, Venkadesh Sarkarai Nadar, Masafumi Yoshinaga, Barry P Rosen

Journal: Environ Microbiol

PubMed ID: 35229439

Doi: 10.1111/1462-2920.15957

Products & Services: Plasmid DNA Preparation

Resveratrol Blunts Mitochondrial Loss in Slow and Mixed Skeletal Muscle Phenotypes of Non-Human Primates following a Long-Term High Fat/Sugar Diet

Authors: Jon-Philippe K Hyatt, Rafael de Cabo, Julie A Mattison

Journal: J Diet Suppl

PubMed ID: 35229700

Doi: 10.1080/19390211.2022.2039340

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The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV15 and ranolazine reverses the phenotype

Authors: Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Journal: Clin Sci (Lond)

PubMed ID: 35190819

Doi: 10.1042/CS20211151

Products & Services: Mammalian Expression

Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis

Authors: Jinping Wang, Xuehui Li, Yuchong Wang, Yuyu Li, Fan Shi, Hongyan Diao

Journal: Cell Death Discov

PubMed ID: 35246529

Doi: 10.1038/s41420-022-00904-x

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Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-b1Induced OCT4/Nanog Pathway

Authors: Wenting Li, Xiaoqiong Duan, Chuanlong Zhu, Xiao Liu, Andre J Jeyarajan, Min Xu, Zeng Tu, Qiuju Sheng, Dong Chen, Chuanwu Zhu, Tuo Shao, Zhimeng Cheng, Shadi Salloum, Esperance A Schaefer, Annie J Kruger, Jacinta A Holmes, Raymond T Chung, Wenyu Lin

Journal: J Immunol

PubMed ID: 35022275

Doi: doi/10.4049/jimmunol.2001453

Products & Services: PCR Cloning and Subcloning

CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Authors: Ling Yi , Xin Jin , Jinghui Wang , Zhuohong Yan , Xu Cheng , Tao Wen , Bin Yang , Xiaojue Wang , Nanying Che , Zhidong Liu and Hongtao Zhang

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2022.771809

Products & Services: Insect Expression

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

Authors: Jianmei Hou , Elizabeth V Nguyen , Minglyanna Surudoi , Michael J Roy , Onisha Patel , Isabelle S Lucet , Xiuquan Ma , Roger J Daly

Journal: Sci Signal

PubMed ID: 35192416

Doi: 10.1126/scisignal.abj3

Products & Services: PCR Cloning and Subcloning Gene Synthesis

Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells

Authors: Shenglong Zhu , Wei Wang , Jingwei Zhang , Siyu Ji , Zhe Jing , Yong Q Chen

Journal: Cell Mol Biol Lett

PubMed ID: 35109789

Doi: 10.1186/s11658-022-00314-y

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Structural characterization of the Myxococcus xanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism

Authors: Elif Eren, Bing Wang, Dennis C Winkler, Norman R Watts, Alasdair C Steven, Paul T Wingfield

Journal: Structure

PubMed ID: 35150605

Doi: 10.1016/j.str.2022.01.008

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Optical Sensors and Actuators for Probing Proximity-Dependent Biotinylation in Living Cells

Authors: Rui Chen, Ningxia Zhang, Yubin Zhou, Ji Jing

Journal: Front Cell Neurosci

PubMed ID: 35250484

Doi: 10.3389/fncel.2022.801644

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Robust and Functional Immune Memory Up to 9 Months After SARS-CoV-2 Infection: A Southeast Asian Longitudinal Cohort

Authors: Hoa Thi My Vo, Alvino Maestri, Heidi Auerswald, Sopheak Sorn, Sokchea Lay, Heng Seng, Sotheary Sann, Nisa Ya, Polidy Pean, Philippe Dussart, Olivier Schwartz, Sovann Ly, Timothée Bruel, Sowath Ly, Veasna Duong, Erik A Karlsson, Tineke Cantaert

Journal: Front Immunol

PubMed ID: 35185909

Doi: 10.3389/fimmu.2022.817905

Products & Services: Proteins, Expression, Isolation and Analysis

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

Authors: Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder

Journal: Nat Commun

PubMed ID: 35149678

Doi: 10.1038/s41467-022-28396-4

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Defining molecular glues with a dual-nanobody cannabidiol sensor

Authors: Shiyun Cao, Shoukai Kang, Haibin Mao, Jiayu Yao, Liangcai Gu, Ning Zheng

Journal: Nat Commun

PubMed ID: 35145136

Doi: 10.1038/s41467-022-28507-1

Products & Services: Mammalian Expression

Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions

Authors: Fin J Milder, Mandy Jongeneelen, Tina Ritschel, Pascale Bouchier, Ilona J M Bisschop, Martijn de Man, Daniel Veldman, Lam Le, Baerbel Kaufmann, Mark J G Bakkers, Jarek Juraszek, Boerries Brandenburg, Johannes P M Langedijk

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35131851

Doi: 10.1073/pnas.2115379119

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T cell receptors employ diverse strategies to target a p53 cancer neoantigen

Authors: Daichao Wu, Ragul Gowathaman, Brian G Pierce, Roy A Mariuzza

Journal: J Biol Chem

PubMed ID: 35124005

Doi: 10.1016/j.jbc.2022.101684

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Evolution and conserved functionality of organ size and shape regulator PEAPOD

Authors: Ruth Cookson, Somrutai Winichayakul, Hong Xue, Kim Richardson, Roger Moraga, Aurelie Laugraud, Ambarish Biswas, Greg Bryan, Nick Roberts

Journal: PLoS ONE

PubMed ID: 35148336

Doi: 10.1371/journal.pone.0263928

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Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial

Authors: Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G S Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M R Pereira, Clóvis Artur Silva, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35193873

Doi: 10.1136/annrheumdis-2021-221916

Products & Services: Proteins, Expression, Isolation and Analysis

Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events

Authors: Siew C Ng, Ye Peng, Lin Zhang, Chris Kp Mok, Shilin Zhao, Amy Li, Jessica Yl Ching, Yingzhi Liu, Shuai Yan, Dream L S Chan, Jie Zhu, Chunke Chen, Adrian Ch Fung, Kenneth Ky Wong, David Sc Hui, Francis Kl Chan, Hein M Tun

Journal: Gut

PubMed ID: 35140064

Doi: 10.1136/gutjnl-2021-326563

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Inhibition of base editors with anti-deaminases derived from viruses

Authors: Zhiquan Liu, Siyu Chen, Liangxue Lai, Zhanjun Li

Journal: Nat Commun

PubMed ID: 35105899

Doi: 10.1038/s41467-022-28300-0

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Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis

Authors: Kevin Yau, Christopher T Chan, Kento T Abe, Yidi Jiang, Mohammad Atiquzzaman, Sarah I Mullin, Ellen Shadowitz, Lisa Liu, Ema Kostadinovic, Tatjana Sukovic, Anny Gonzalez, Margaret E McGrath-Chong, Matthew J Oliver, Jeffrey Perl, Jerome A Leis, Shelly Bolotin, Vanessa Tran, Adeera Levin, Peter G Blake, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: CMAJ

PubMed ID: 35115375

Doi: 10.1503/cmaj.211881

Products & Services: Mammalian Expression

The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs

Authors: Margarida Saramago, Vanessa G Costa, Caio S Souza, Cátia Bárria, Susana Domingues, Sandra C Viegas, Diana Lousa, Cláudio M Soares, Cecília M Arraiano, Rute G Matos

Journal: Microorganisms

PubMed ID: 35208797

Doi: 10.3390/microorganisms10020342

Products & Services: Gene Synthesis

Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination Strategies

Authors: Matthaios Speletas, Ioanna Voulgaridi, Styliani Sarrou, Aikaterini Dadouli, Varvara A Mouchtouri, Dimitrios J Nikoulis, Maria Tsakona, Maria A Kyritsi, Athanasia-Marina Peristeri, Ioanna Avakian, Asimina Nasika, Paraskevi C Fragkou, Charalampos D Moschopoulos, Stamatia Zoubouneli, Ilias Onoufriadis, Lemonia Anagnostopoulos, Alexia Matziri, Georgia Papadamou, Aikaterini Theodoridou, Sotirios Tsiodras, Christos Hadjichristodoulou

Journal: Vaccines (Basel)

PubMed ID: 35214774

Doi: 10.3390/vaccines10020316

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

Authors: Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina

Journal: Nat Commun

PubMed ID: 35115561

Doi: 10.1038/s41467-022-28360-2

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Sensitivity of eight types of ALK fusion variant to alectinib in ALK-transformed cells

Authors: Koh Furugaki, Naoki Harada, Yasushi Yoshimura

Journal: Anticancer Drugs

PubMed ID: 34520436

Doi: 10.1097/CAD.0000000000001249

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