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DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice

Authors: Jinni Chen, Yao Deng, Baoying Huang, Di Han, Wen Wang, Mengjing Huang, Chengcheng Zhai, Zhimin Zhao, Ren Yang, Ying Zhao, Wenling Wang, Desheng Zhai, Wenjie Tan

Journal: Front Immunol

PubMed ID: 35281016

Doi: 10.3389/fimmu.2022.827605

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Human Milk SARS-CoV-2 Antibodies up to 6 Months After Vaccination

Authors: Stephanie E Perez, Luis Diego Luna Centeno, Wesley A Cheng, Carolyn Jennifer Marentes Ruiz, Yesun Lee, Zion Congrave-Wilson, Rebecca L Powell, Lisa Stellwagen, Pia S Pannaraj

Journal: Pediatrics

PubMed ID: 34981122

Doi: 10.1542/peds.2021-054260

Products & Services: Mammalian Expression

Lectin galactoside-binding soluble 3 binding protein mediates methotrexate resistance in choriocarcinoma cell lines

Authors: XiaoJing Chen, Yite Xue, Lingfang Wang, Yang Weng, Sen Li, Weiguo Lü, Xing Xie, Xiaodong Cheng

Journal: Bioengineered

PubMed ID: 35038949

Doi: 10.1080/21655979.2021.2022844

Products & Services: Proteins, Expression, Isolation and Analysis

Dimer dissociation is a key energetic event in the fold-switch pathway of KaiB

Authors: Maira Rivera, Pablo Galaz-Davison, Ignacio Retamal-Farfán, Elizabeth A Komives, César A Ramírez-Sarmiento

Journal: Biophys J

PubMed ID: 35151633

Doi: 10.1016/j.bpj.2022.02.012

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Ca Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells

Authors: Beibei Wu, Jin Seok Woo, Zuoming Sun, Sonal Srikanth, Yousang Gwack

Journal: J Immunol

PubMed ID: 35217583

Doi: 10.4049/jimmunol.2100871

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Immunological characterization of chicken tumor necrosis factor-α (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α

Authors: Mingmin Lu, Youngsub Lee, Charles Li, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 35157961

Doi: 10.1016/j.dci.2022.104374

Products & Services: Proteins, Expression, Isolation and Analysis

Polycystin-1 and hydrostatic pressure are implicated in glioblastoma pathogenesis in vitro

Authors: Ilianna Zoi, Antonios N Gargalionis, Kostas A Papavassiliou, Narjes Nasiri-Ansari, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassiliou

Journal: J Cell Mol Med

PubMed ID: 35106909

Doi: 10.1111/jcmm.17212

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ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

Authors: Lifeng Qin, Xin Liu, Li'na Lan, Xiaoping Lv

Journal: Int J Gen Med

PubMed ID: 35173468

Doi: 10.2147/IJGM.S343968

Products & Services: GenParts™ DNA Fragments

Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

Authors: Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan

Journal: Hum Vaccin Immunother

PubMed ID: 35209809

Doi: 10.1080/21645515.2022.2029111

Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

Authors: Kuan-Ting Liu, Yu-Nong Gong, Chung-Guei Huang, Peng-Nien Huang, Kar-Yee Yu, Hou-Chen Lee, Sun-Che Lee, Huan-Jung Chiang, Yu-An Kung, Yueh-Te Lin, Mei-Jen Hsiao, Po-Wei Huang, Sheng-Yu Huang, Hsin-Tai Wu, Chih-Ching Wu, Rei-Lin Kuo, Kuan-Fu Chen, Chuan-Tien Hung, Kasopefoluwa Y Oguntuyo, Christian S Stevens, Shreyas Kowdle, Hsin-Ping Chiu, Benhur Lee, Guang-Wu Chen, Shin-Ru Shih

Journal: mSphere

PubMed ID: 35107336

Doi: 10.1128/msphere.00883-21

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Authors: Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

Products & Services: Bacterial Expression

IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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Impact of Superparamagnetic Iron Oxide Nanoparticles on THP-1 Monocytes and Monocyte-Derived Macrophages

Authors: Christina Polasky, Tim Studt, Ann-Kathrin Steuer, Kristin Loyal, Kerstin Lüdtke-Buzug, Karl-Ludwig Bruchhage, Ralph Pries

Journal: Front Mol Biosci

PubMed ID: 35211509

Doi: 10.3389/fmolb.2022.811116

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: Emerg Infect Dis

PubMed ID: 35076009

Doi: 10.3201/eid2802.211725

Products & Services: Recombinant Proteins

SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study

Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park

Journal: J Infect Dis

PubMed ID: 35104871

Doi: 10.1093/infdis/jiac035

SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study

Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park

Journal: J Infect Dis

PubMed ID: 35104871

Doi: 10.1093/infdis/jiac035

Development of an efficient and precise adenine base editor (ABE) with expanded target range in allotetraploid cotton (Gossypium hirsutum)

Authors: Guanying Wang, Zhongping Xu, Fuqiu Wang, Yuefan Huang, Yanfeng Xin, Sijia Liang, Bo Li, Huan Si, Lin Sun, Qiongqiong Wang, Xiao Ding, Xiangqian Zhu, Luo Chen, Lu Yu, Keith Lindsey, Xianlong Zhang, Shuangxia Jin

Journal: BMC Biol

PubMed ID: 35164736

Doi: 10.1186/s12915-022-01232-3

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Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

Authors: Jacqueto Zephyr, Desaboini Nageswara Rao, Sang V Vo, Mina Henes, Klajdi Kosovrasti, Ashley N Matthew, Adam K Hedger, Jennifer Timm, Elise T Chan, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer

Journal: J Mol Biol

PubMed ID: 35183560

Doi: 10.1016/j.jmb.2022.167503

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WIN site inhibition disrupts a subset of WDR5 function

Authors: Andrew J Siladi, Jing Wang, Andrea C Florian, Lance R Thomas, Joy H Creighton, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Gregory C Howard, Stephen W Fesik, April M Weissmiller, Qi Liu, William P Tansey

Journal: Sci Rep

PubMed ID: 35115608

Doi: 10.1038/s41598-022-05947-9

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Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

Authors: Gregor L Weiss, Fabian Eisenstein, Ann-Katrin Kieninger, Jingwei Xu, Hannah A Minas, Milena Gerber, Miki Feldmüller, Iris Maldener, Karl Forchhammer, Martin Pilhofer

Journal: Nat Microbiol

PubMed ID: 35165386

Doi: 10.1038/s41564-021-01055-y

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An Enhanced Hybrid Screening Approach to Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library

Authors: Shuhua G Li, Kai S Yang, Lauren R Blankenship, Chia-Chuan D Cho, Shiqing Xu, Hongbin Wang, Wenshe Ray Liu

Journal: Front Chem

PubMed ID: 35252116

Doi: 10.3389/fchem.2022.816576

Products & Services: Proteins, Expression, Isolation and Analysis

Immunodominant conformational and linear IgE epitopes lie in a single segment of Ara h 2

Authors: Stéphane Hazebrouck, Sarita U Patil, Blanche Guillon, Nicole Lahood, Stephen C Dreskin, Karine Adel-Patient, Hervé Bernard

Journal: J Allergy Clin Immunol

PubMed ID: 35150723

Doi: 10.1016/j.jaci.2021.12.796

Products & Services: Plasmid DNA Preparation

Establishment of a lncRNA-miRNA-mRNA network in a rat model of atrial fibrosis by whole transcriptome sequencing

Authors: Bo Zhao, Weiding Wang, Yu Liu, Siyu Guan, Manman Wang, Fang Song, Wenfeng Shangguan, Shuai Miao, Xiaowei Zhang, Huijia Liu, Enzhao Liu, Xue Liang

Journal: J Interv Card Electrophysiol

PubMed ID: 35124782

Doi: 10.1007/s10840-022-01120-4

Products & Services: Custom DNA/RNA Oligos

Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors

Authors: Joel Wellbourne-Wood, Marc Briquet, Maxime Alessandri, Francesca Binda, Maylis Touya, Jean-Yves Chatton

Journal: Biosensors (Basel)

PubMed ID: 35323413

Doi: 10.3390/bios12030143

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Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population

Authors: Sonja Kopanja, Pia Gattinger, Klara Schmidthaler, Justyna Sieber, Katarzyna Niepodziana, Thomas Schlederer, Lukas Weseslindtner, Karin Stiasny, Florian Götzinger, Winfried F Pickl, Thomas Frischer, Rudolf Valenta, Zsolt Szépfalusi

Journal: Pediatr Allergy Immunol

PubMed ID: 35212039

Doi: 10.1111/pai.13737

Products & Services: Bacterial Expression

From musk to body odor: Decoding olfaction through genetic variation

Authors: Bingjie Li, Marissa L Kamarck, Qianqian Peng, Fei-Ling Lim, Andreas Keller, Monique A M Smeets, Joel D Mainland, Sijia Wang

Journal: PLoS Genet

PubMed ID: 35113854

Doi: 10.1371/journal.pgen.1009564

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Detection of SARS-CoV-2 Omicron variant (B11529) infection of white-tailed deer

Authors: Kurt J Vandegrift, Michele Yon, Meera Surendran-Nair, Abhinay Gontu, Saranya Amirthalingam, Ruth H Nissly, Nicole Levine, Tod Stuber, Anthony J DeNicola, Jason R Boulanger, Nathan Kotschwar, Sarah Grimké Aucoin, Richard Simon, Katrina Toal, Randall J Olsen, James J Davis, Dashzeveg Bold, Natasha N Gaudreault, Juergen A Richt, James M Musser, Peter J Hudson, Vivek Kapur, Suresh V Kuchipudi

Journal: biorxiv

PubMed ID: 35169802

Doi: 10.1101/2022.02.04.479189

Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E coli

Authors: Parthasarathy Manikandan, Sankaran Sandhya, Kavyashree Nadig, Souradip Paul, Narayanaswamy Srinivasan, Ulli Rothweiler, Mahavir Singh

Journal: Nucleic Acids Res

PubMed ID: 35018473

Doi: 10.1093/nar/gkab1264

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SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

Authors: David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse Erasmus

Journal: Elife

PubMed ID: 35191378

Doi: 10.7554/eLife.75537

Products & Services: Proteins, Expression, Isolation and Analysis

The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice

Authors: Spencer Iner Thomas Berg, Justin Knapp, Marsela Braunstein, Cody Shirriff

Journal: Autoimmunity

PubMed ID: 35137667

Doi: 10.1080/08916934.2022.2027921

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Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

Products & Services: Recombinant Antibody Expression

Genome-wide association study and functional follow-up identifies 14q12 as a candidate risk locus for cervical cancer

Authors: Dhanya Ramachandran, Joe Dennis, Laura Fachal, Peter Schürmann, Kristine Bousset, Fabienne Hülse, Qianqian Mao, Yingying Wang, Matthias Jentschke, Gerd Böhmer, Hans-Georg Strauß, Christine Hirchenhain, Monika Schmidmayr, Florian Müller, Ingo Runnebaum, Alexander Hein, Frederik Stübs, Martin Koch, Matthias Ruebner, Matthias W Beckmann, Peter A Fasching, Alexander Luyten, Matthias Dürst, Peter Hillemanns, Douglas F Easton, Thilo Dörk

Journal: Hum Mol Genet

PubMed ID: 35157032

Doi: 10.1093/hmg/ddac031

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Highly Stable Buffer-Based Zinc Oxide/Reduced Graphene Oxide Nanosurface Chemistry for Rapid Immunosensing of SARS-CoV-2 Antigens

Authors: Fatemeh Haghayegh, Razieh Salahandish, Mohsen Hassani, Amir Sanati-Nezhad

Journal: ACS Appl Mater Interfaces

PubMed ID: 35172574

Doi: 10.1021/acsami.1c24475

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a Nanoparticle Multiepitope DNA Vaccine against Virulent Infectious Bronchitis Virus Challenge

Authors: Yifeng Qin, Qingyuan Teng, Delan Feng, Yu Pei, Ye Zhao, Guozhong Zhang

Journal: J Immunol

PubMed ID: 35217582

Doi: 10.4049/jimmunol.2100909

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Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages

Authors: Mingxin Liu, Guizhou Tao, Yiming Cao, Yu Hu, Zhe Zhang

Journal: J Biochem Mol Toxicol

PubMed ID: 35179253

Doi: 10.1002/jbt.22994

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Development of a Test Card Based on Colloidal Gold Immunochromatographic Strips for Rapid Detection of Antibodies against Theileria equi and Babesia caballi

Authors: Guangpu Yang, Kewei Chen, Wei Guo, Zhe Hu, Ting Qi, Diqiu Liu, Yaoxin Wang, Cheng Du, Xiaojun Wang

Journal: Microbiol Spectr

PubMed ID: 35196786

Doi: 10.1128/spectrum.02411-21

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide identification and characterization of aquaporins in mangrove plant Kandelia obovata and its role in response to the intertidal environment

Authors: Zejun Guo, Dongna Ma, Jing Li, Mingyue Wei, Ludan Zhang, Lichun Zhou, Xiaoxuan Zhou, Shanshan He, Lin Wang, Yingjia Shen, Qingshun Quinn Li, Hai-Lei Zheng

Journal: Plant Cell Environ

PubMed ID: 35141923

Doi: 10.1111/pce.14286

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Cytolysin A-mediated protein exportation efficiency and its role in enhancing the fitness of live recombinant Salmonella Typhi vaccine strain

Authors: F-K Loh, S Nathan, S-C Chow, C-M Fang

Journal: Lett Appl Microbiol

PubMed ID: 35138654

Doi: 10.1111/lam.13669

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Distinct Homologous and Variant-Specific Memory B-Cell and Antibody Response Over Time after SARS-CoV-2 mRNA Vaccination

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: J Infect Dis

PubMed ID: 35137144

Doi: 10.1093/infdis/jiac042

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Distinct Homologous and Variant-Specific Memory B-Cell and Antibody Response Over Time after SARS-CoV-2 mRNA Vaccination

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: J Infect Dis

PubMed ID: 35137144

Doi: 10.1093/infdis/jiac042

Products & Services: Recombinant Proteins

Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

Authors: Minghua Deng, Jinhua Li, Bichen Xiao, Zhanpeng Ren, Ziqin Li, Haiyang Yu, Jiashen Li, Jianying Wang, Zhaowei Chen, Xianbao Wang

Journal: Anal Chem

PubMed ID: 35147418

Doi: 10.1021/acs.analchem.1c05309

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Biochemical Screening of Potent Zika Virus Protease Inhibitors

Authors: Camila Coelho, Gloria Gallo, Leon Hardy, Maria Elena Bottazzi, Claudia Campos, Martin Würtele

Journal: ChemMedChem

PubMed ID: 35104396

Doi: 10.1002/cmdc.202100695

Products & Services: Proteins, Expression, Isolation and Analysis

TAMpepK Suppresses Metastasis through the Elimination of M2-Like Tumor-Associated Macrophages in Triple-Negative Breast Cancer

Authors: Chanju Lee, Soyoung Kim, Chanmi Jeong, Inhee Cho, Juyeon Jo, Ik-Hwan Han, Hyunsu Bae

Journal: Int J Mol Sci

PubMed ID: 35216272

Doi: 10.3390/ijms23042157

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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration

Authors: Elena I Ilina, Camille Cialini, Dietlind L Gerloff, Maitane Duarte Garcia-Escudero, Céline Jeanty, Marie-Laëtitia Thézénas, Antoine Lesur, Vincent Puard, François Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gérardy, Gunnar Dittmar, Simone P Niclou, Tanja Müller, Michel Mittelbronn

Journal: iScience

PubMed ID: 35198895

Doi: 10.1016/j.isci.2022.103842

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Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance Gene

Authors: Yue Zhao, Zhengzheng Cao, Luqing Cui, Tianyu Hu, Kaixuan Guo, Fan Zhang, Xiangru Wang, Zhong Peng, Quan Liu, Menghong Dai

Journal: Front Microbiol

PubMed ID: 35250901

Doi: 10.3389/fmicb.2021.773664

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel TRIM9 Protein Promotes NF-κB Activation Through Interacting With LvIMD in Shrimp During WSSV Infection

Authors: Mingzhe Sun, Shihao Li, Songjun Jin, Xuechun Li, Jianhai Xiang, Fuhua Li